SCS Fall Meeting 2021
10. September 2021, Online Conference
Introduction
Philip Morris international (PMI) is leading a transformation in the tobacco industry to create a smoke-free future and ultimately replace cigarettes with smoke-free products to the benefit of adults who would otherwise continue to smoke, society, the company, its shareholders and its other stakeholders.
By placing science and innovation front and center as a driving force for the future, PMI is focusing its resources on developing scientifically substantiating, and responsibility commercializing smoke-free products that, while not risk-free, are a much better choice for adult smokers than continuing to smoke cigarettes. Its R&D efforts follow practices used in the pharmaceutical industry and guidance from the U.S. Food and Drug Administration (FDA), and are led by a team composed of more than 430 world-class scientists, engineers, and experts.
PMI Science Booklet
The PMI Science Booklet condenses the information about our smoke-free products, providing the most up-to-date findings from our assessment program while also digging deeper into the details of the product's chemistry. the effects of switching on health risks, and a section dedicated to independent studies and reviews.
to explore the most up-to-date information about PMI's scientific assessment program of our smoke-free products.
The following infographic is extracted from the PMIScience Booklet, and summarizes the Aerosol chemistry Targeted analysis and Untargeted analytical screening.
Chemistry Research
Relevant materials can be downloaded here
Untargeted chemical characterization of the aerosol generated by a heated tobacco product
Non-targeted screening by LC -HRAM-MS for chemical characterization of smoke-free products
Non-targeted chemical characterization of complex matrices by nominal and high-resolution accurate-mass GCxGC-TOFMS
Characterization of aerosol exposure, metabolism, and pharmacokinetics for toxicological assessment using in vitro organotypic airway models and organ-on-a-chip liver models (non-audio)
Posters
Characterization of aerosol deposition on human organotypic respiratory epithelial tissue exposed at the air-liquid interface and metabolism assessment
An automated workflow for high-throughput nicotine quantitation using high-performance liquid chromatography coupled to high-resolution accurate mass spectrometry for prototype testing
Formaldehyde-Glycerol Hemiacetal - Absence of "Hidden" Formaldehyde in THS 2.2 Aerosols
Bioactivation of Furans by Human Lung and Liver Microsomes and S9
Applicability of Different Soft Nucleophiles for Screening Reactive Metabolites Resulting from Microsomal Activation of Furan Mixtures and Cigarette Smoke
Non-targeted screening using GCxGC-TOFMS for in-depth chemical characterization of aerosol from a heat-not-burn tobacco product
Computer-Assisted Structure Identification (CASI) for high-throughput identification of small molecules using GC-GC-HRAM-TOFMS high-resolution accurate mass spectrometry
Biological Systems Research
Relevant materials can be downloaded here
Delivery efficiencies of constituents of combustion-derived aerosols across T the air-liquid interface during in vitro exposures
Characterization of aerosol delivery in the Vitrocell
Development, validation, and characterization of methods for generating, collecting, and using aerosols from heat-not-burn tobacco products