DNA-ferrocene as two-step-mechanophore
Since many years, researchers are interested in sandwich-type complexes that can be used in various areas like in catalysis, in electrochemistry, in agrochemical applications or for the production of pharmaceuticals and flavours.[1, 2] Recently, we have shown that ferrocene can be used as a mechanophore in polymers, hence as preferential breaking point in poly methyl-acrylate and polyurethane.
We have now introduced additional functionality by associating the ferrocene moieties via a linker  to a DNA duplex. Embedding such an entity into a polymer is expected to give rise to a two-step mechanophore  (Figure 1) in which first the H-bonds of DNA, and then the sandwich-complex are cleaved as increasing force is exerted. Mismatches that have been introduced in the DNA pairing, have an influence on the mechanical strength of the mechanophore.
 T. J. Colacot, N. S. Hosmane, Z. Anorg. Allg. Chem., 2005, 631, 2659-2668.
 C. Sui, Y. Zhou, M. Wang, H. Yin, P. Wang, S. Ai, Sensors and Actuators B., 2018, 514-521.
 M. Di Giannantonio, M. A. Ayer, E. Vester-Sesto, M. Lattuada, C. Weder, K. M. Fromm, Angew.Chem.Int. Ed., 2018, 57, 11445 –11450.
 R. Claus, J. P. Lewtak, T. J. Muller, J. C. Swarts, J. Organomet. Chem., 2013, 740, 61-69.
 J. Li, C. Nagamani, J. S. Moore, Acc. Chem. Res., 2015, 48 (8), 2181–2190.